1ttn

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{{STRUCTURE_1ttn| PDB=1ttn | SCENE= }}
{{STRUCTURE_1ttn| PDB=1ttn | SCENE= }}
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'''Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells'''
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===Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells===
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==Overview==
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The previously identified dendritic cell-derived ubiquitin-like protein (DC-UbP) was implicated in cellular differentiation and apoptosis. Sequence alignment suggested that it contains a ubiquitin-like (UbL) domain in the C terminus. Here, we present the solution NMR structure and backbone dynamics of the UbL domain of DC-UbP. The overall structure of the domain is very similar to that of Ub despite low similarity (&lt;30%) in amino-acid sequence. One distinct feature of the domain structure is its highly positively charged surface that is different from the corresponding surfaces of the well-known UbL modifiers, Ub, NEDD8, and SUMO-1. The key amino-acid residues responsible for guiding polyubiquitinated proteins to proteasome degradation in Ub are not conserved in the UbL domain. This implies that the UbL domain of DC-UbP may have its own specific interaction partners with other yet unknown cellular functions related to the Ub pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 15987890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15987890}}
==About this Structure==
==About this Structure==
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1TTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTN OCA].
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1TTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTN OCA].
==Reference==
==Reference==
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[[Category: Solution structure]]
[[Category: Solution structure]]
[[Category: Ubiquitin-like domain]]
[[Category: Ubiquitin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:20:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:28:54 2008''

Revision as of 21:29, 27 July 2008

Image:1ttn.png

Template:STRUCTURE 1ttn

Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells

Template:ABSTRACT PUBMED 15987890

About this Structure

1TTN is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells., Gao YG, Song AX, Shi YH, Chang YG, Liu SX, Yu YZ, Cao XT, Lin DH, Hu HY, Protein Sci. 2005 Aug;14(8):2044-50. Epub 2005 Jun 29. PMID:15987890

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