2a2b

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[[Image:2a2b.gif|left|200px]]
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{{Seed}}
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[[Image:2a2b.png|left|200px]]
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{{STRUCTURE_2a2b| PDB=2a2b | SCENE= }}
{{STRUCTURE_2a2b| PDB=2a2b | SCENE= }}
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'''Curvacin A'''
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===Curvacin A===
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==Overview==
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The 3D structure of the membrane-permeabilizing 41-mer pediocin-like antimicrobial peptide curvacin A produced by lactic acid bacteria has been studied by NMR spectroscopy. In DPC micelles, the cationic and hydrophilic N-terminal half of the peptide forms an S-shaped beta-sheet-like domain stabilized by a disulfide bridge and a few hydrogen bonds. This domain is followed by two alpha-helices: a hydrophilic 6-mer helix between residues 19 and 24 and an amphiphilic/hydrophobic 11-mer helix between residues 29 and 39. There are two hinges in the peptide, one at residues 16-18 between the N-terminal S-shaped beta-sheet-like structure and the central 6-mer helix and one at residues 26-28 between the central helix and the 11-mer C-terminal helix. The latter helix is the only amphiphilic/hydrophobic part of the peptide and is thus presumably the part that penetrates into the hydrophobic phase of target-cell membranes. The hinge between the two helices may introduce the flexibility that allows the helix to dip into membranes. The helix-hinge-helix structure in the C-terminal half of curvacin A clearly distinguishes this peptide from the other pediocin-like peptides whose structures have been analyzed and suggests that curvacin A along with the structural homologues enterocin P and carnobacteriocin BM1 belong to a subgroup of the pediocin-like family of antimicrobial peptides.
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(as it appears on PubMed at http://www.pubmed.gov), where 16331975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16331975}}
==About this Structure==
==About this Structure==
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2A2B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_curvatus Lactobacillus curvatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2B OCA].
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2A2B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_curvatus Lactobacillus curvatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2B OCA].
==Reference==
==Reference==
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[[Category: Beta-sheet like strukture]]
[[Category: Beta-sheet like strukture]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:29:14 2008''

Revision as of 21:29, 27 July 2008

Image:2a2b.png

Template:STRUCTURE 2a2b

Curvacin A

Template:ABSTRACT PUBMED 16331975

About this Structure

2A2B is a Single protein structure of sequence from Lactobacillus curvatus. Full experimental information is available from OCA.

Reference

Three-dimensional structure in lipid micelles of the pediocin-like antimicrobial peptide curvacin A., Haugen HS, Fimland G, Nissen-Meyer J, Kristiansen PE, Biochemistry. 2005 Dec 13;44(49):16149-57. PMID:16331975

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