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1ozi

From Proteopedia

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[[Image:1ozi.gif|left|200px]]
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{{STRUCTURE_1ozi| PDB=1ozi | SCENE= }}
{{STRUCTURE_1ozi| PDB=1ozi | SCENE= }}
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'''The alternatively spliced PDZ2 domain of PTP-BL'''
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===The alternatively spliced PDZ2 domain of PTP-BL===
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==Overview==
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PTP-BL is a large phosphatase that is implicated in cellular processes as diverse as cytokinesis, actin-cytoskeletal rearrangement, and apoptosis. Five PDZ domains mediate its cellular role by binding to the C termini of target proteins, forming multiprotein complexes. The second PDZ domain (PDZ2) binds to the C termini of the tumor suppressor protein APC and the LIM domain-containing protein RIL; however, in one splice variant, PDZ2as, a 5 residue insertion abrogates this binding. The insert causes distinct structural and dynamical changes in the alternatively spliced PDZ2: enlarging the L1 loop between beta2 and beta3, both lengthening and changing the orientation of the alpha2 helix, giving the base of the binding pocket less flexibility to accommodate ligands, and destabilizing the entire domain. These changes render the binding pocket incapable of binding C termini, possibly having implications in the functional role of PTP-BL.
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(as it appears on PubMed at http://www.pubmed.gov), where 14725761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14725761}}
==About this Structure==
==About this Structure==
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1OZI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZI OCA].
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1OZI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZI OCA].
==Reference==
==Reference==
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[[Category: Reversion induced lim]]
[[Category: Reversion induced lim]]
[[Category: Ril]]
[[Category: Ril]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:28:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:30:26 2008''

Revision as of 21:30, 27 July 2008

Image:1ozi.png

Template:STRUCTURE 1ozi

The alternatively spliced PDZ2 domain of PTP-BL

Template:ABSTRACT PUBMED 14725761

About this Structure

1OZI is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

A closed binding pocket and global destabilization modify the binding properties of an alternatively spliced form of the second PDZ domain of PTP-BL., Walma T, Aelen J, Nabuurs SB, Oostendorp M, van den Berk L, Hendriks W, Vuister GW, Structure. 2004 Jan;12(1):11-20. PMID:14725761

Page seeded by OCA on Mon Jul 28 00:30:26 2008

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