1uxs
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1uxs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uxs, resolution 1.55Å" /> '''CRYSTAL STRUCTURE O...)
Next diff →
Revision as of 18:15, 29 October 2007
|
CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE LATENT MEMBRANE PROTEIN 2 PEPTIDE (LMP2)OF EPSTEIN-BARR VIRUS
Overview
Molecular mimicry is discussed as a possible mechanism that may contribute, to the development of autoimmune diseases. It could also be involved in, the differential association of the human major histocompatibility, subtypes HLA-B(*)2705 and HLA-B(*)2709 with ankylosing spondylitis. These, two subtypes differ only in residue 116 of the heavy chain (Asp in, B(*)2705 and His in B(*)2709), but the reason for the differential disease, association is not understood. Using x-ray crystallography, we show here, that the viral peptide pLMP2 (RRRWRRLTV, derived from latent membrane, protein 2 (residues 236-244) of Epstein-Barr virus) is presented by the, B(*)2705 and B(*)2709 molecules in two drastically deviating, conformations. Extensive structural similarity between pLMP2 and the, self-peptide ... [(full description)]
About this Structure
1UXS is a [Protein complex] structure of sequences from [Homo sapiens] with GOL as [ligand]. Full crystallographic information is available from [OCA].
Reference
Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes., Fiorillo MT, Ruckert C, Hulsmeyer M, Sorrentino R, Saenger W, Ziegler A, Uchanska-Ziegler B, J Biol Chem. 2005 Jan 28;280(4):2962-71. Epub 2004 Nov 10. PMID:15537660
Page seeded by OCA on Mon Oct 29 20:20:17 2007
