1muj

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[[Image:1muj.gif|left|200px]]
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{{STRUCTURE_1muj| PDB=1muj | SCENE= }}
{{STRUCTURE_1muj| PDB=1muj | SCENE= }}
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'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''
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===Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide===
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==Overview==
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Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
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The line below this paragraph, {{ABSTRACT_PUBMED_12589760}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12589760 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12589760}}
==About this Structure==
==About this Structure==
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[[Category: I-ab]]
[[Category: I-ab]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:34:04 2008''

Revision as of 21:34, 27 July 2008

Image:1muj.png

Template:STRUCTURE 1muj

Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide

Template:ABSTRACT PUBMED 12589760

About this Structure

1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760

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