1wwl

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[[Image:1wwl.gif|left|200px]]
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{{Seed}}
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[[Image:1wwl.png|left|200px]]
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{{STRUCTURE_1wwl| PDB=1wwl | SCENE= }}
{{STRUCTURE_1wwl| PDB=1wwl | SCENE= }}
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'''Crystal structure of CD14'''
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===Crystal structure of CD14===
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==Overview==
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Lipopolysaccharide, the endotoxin of Gram-negative bacteria, induces extensive immune responses that can lead to fatal septic shock syndrome. The core receptors recognizing lipopolysaccharide are CD14, TLR4, and MD-2. CD14 binds to lipopolysaccharide and presents it to the TLR4/MD-2 complex, which initiates intracellular signaling. In addition to lipopolysaccharide, CD14 is capable of recognizing a few other microbial and cellular products. Here, we present the first crystal structure of CD14 to 2.5 angstroms resolution. A large hydrophobic pocket was found on the NH2-terminal side of the horseshoe-like structure. Previously identified regions involved in lipopolysaccharide binding map to the rim and bottom of the pocket indicating that the pocket is the main component of the lipopolysaccharide-binding site. Mutations that interfere with lipopolysaccharide signaling but not with lipopolysaccharide binding are also clustered in a separate area near the pocket. Ligand diversity of CD14 could be explained by the generous size of the pocket, the considerable flexibility of the rim of the pocket, and the multiplicity of grooves available for ligand binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_15644310}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15644310 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15644310}}
==About this Structure==
==About this Structure==
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[[Category: Cd14]]
[[Category: Cd14]]
[[Category: Lp]]
[[Category: Lp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:14:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:35:01 2008''

Revision as of 21:35, 27 July 2008

Image:1wwl.png

Template:STRUCTURE 1wwl

Crystal structure of CD14

Template:ABSTRACT PUBMED 15644310

About this Structure

1WWL is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of CD14 and its implications for lipopolysaccharide signaling., Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, Lee H, Lee JO, J Biol Chem. 2005 Mar 25;280(12):11347-51. Epub 2005 Jan 10. PMID:15644310

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