1tmc

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{{STRUCTURE_1tmc| PDB=1tmc | SCENE= }}
{{STRUCTURE_1tmc| PDB=1tmc | SCENE= }}
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'''THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN'''
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===THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN===
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==Overview==
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Class I major histocompatibility complex (MHC) molecules are ternary complexes of the soluble serum protein beta 2-microglobulin, MHC heavy chain, and bound peptide. The first two domains (alpha 1, alpha 2) of the heavy chain create the peptide binding cleft and the surface that contacts the T-cell receptor. The third domain (alpha 3) associates with the T-cell co-receptor, CD8, during T-cell recognition. Here we describe the x-ray crystal structure of a human class I MHC molecule, HLA-Aw68, from which the alpha 3 domain has been proteolytically removed. The resulting molecule shows no gross morphological changes compared to the intact protein. A decameric peptide complexed with the intact HLA-Aw68 is seen to bind to the proteolized molecule in the conventional manner, demonstrating that the alpha 3 domain is not required for the structural integrity of the molecule or for peptide binding.
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{{ABSTRACT_PUBMED_7862664}}
==About this Structure==
==About this Structure==
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Histocompatibility antigen]]
[[Category: Histocompatibility antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:07:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:36:33 2008''

Revision as of 21:36, 27 July 2008

Image:1tmc.png

Template:STRUCTURE 1tmc

THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN

Template:ABSTRACT PUBMED 7862664

About this Structure

1TMC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain., Collins EJ, Garboczi DN, Karpusas MN, Wiley DC, Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1218-21. PMID:7862664

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