3buc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3buc.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3buc.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3buc| PDB=3buc | SCENE= }}
{{STRUCTURE_3buc| PDB=3buc | SCENE= }}
-
'''X-ray structure of human ABH2 bound to dsDNA with Mn(II) and 2KG'''
+
===X-ray structure of human ABH2 bound to dsDNA with Mn(II) and 2KG===
-
==Overview==
+
<!--
-
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 preferentially repair single-stranded DNA (ssDNA) lesions and can repair damaged bases in RNA. Here we show the first crystal structures of AlkB-dsDNA and ABH2-dsDNA complexes, stabilized by a chemical cross-linking strategy. This study reveals that AlkB uses an unprecedented base-flipping mechanism to access the damaged base: it squeezes together the two bases flanking the flipped-out one to maintain the base stack, explaining the preference of AlkB for repairing ssDNA lesions over dsDNA ones. In addition, the first crystal structure of ABH2, presented here, provides a structural basis for designing inhibitors of this human DNA repair protein.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18432238}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18432238 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18432238}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Oxidoreductase/dna complex]]
[[Category: Oxidoreductase/dna complex]]
[[Category: Protein/dna interaction]]
[[Category: Protein/dna interaction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:57:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:39:06 2008''

Revision as of 21:39, 27 July 2008

Image:3buc.png

Template:STRUCTURE 3buc

X-ray structure of human ABH2 bound to dsDNA with Mn(II) and 2KG

Template:ABSTRACT PUBMED 18432238

About this Structure

3BUC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA., Yang CG, Yi C, Duguid EM, Sullivan CT, Jian X, Rice PA, He C, Nature. 2008 Apr 24;452(7190):961-5. PMID:18432238

Page seeded by OCA on Mon Jul 28 00:39:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3buc"
Personal tools