2b2n

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{{STRUCTURE_2b2n| PDB=2b2n | SCENE= }}
{{STRUCTURE_2b2n| PDB=2b2n | SCENE= }}
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'''Structure of transcription-repair coupling factor'''
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===Structure of transcription-repair coupling factor===
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==Overview==
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The transcription repair coupling factor Mfd removes stalled RNA polymerase from DNA lesions and links transcription to UvrABC-dependent nucleotide excision repair in prokaryotes. We report the 2.1A crystal structure of the UvrA-binding N terminus (residues 1-333) of Escherichia coli Mfd (Mfd-N). Remarkably, Mfd-N reveals a fold that resembles the three N-terminal domains of the repair enzyme UvrB. Domain 1A of Mfd adopts a typical RecA fold, domain 1B matches the damage-binding domain of the UvrB, and domain 2 highly resembles the implicated UvrA-binding domain of UvrB. However, Mfd apparently lacks a functional ATP-binding site and does not contain the DNA damage-binding motifs of UvrB. Thus, our results suggest that Mfd might form a UvrA recruitment factor at stalled transcription complexes that architecturally but not catalytically resembles UvrB.
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{{ABSTRACT_PUBMED_16309703}}
==About this Structure==
==About this Structure==
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[[Category: Uvra/b/c repair system]]
[[Category: Uvra/b/c repair system]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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Revision as of 21:42, 27 July 2008

Image:2b2n.png

Template:STRUCTURE 2b2n

Structure of transcription-repair coupling factor

Template:ABSTRACT PUBMED 16309703

About this Structure

2B2N is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs., Assenmacher N, Wenig K, Lammens A, Hopfner KP, J Mol Biol. 2006 Jan 27;355(4):675-83. Epub 2005 Nov 8. PMID:16309703

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