1q8v

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[[Image:1q8v.jpg|left|200px]]
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{{Seed}}
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[[Image:1q8v.png|left|200px]]
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{{STRUCTURE_1q8v| PDB=1q8v | SCENE= }}
{{STRUCTURE_1q8v| PDB=1q8v | SCENE= }}
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'''Pterocarpus angolensis lectin (PAL) in complex with the trimannoside [Man(Alpha1-3)]Man(alpha1-6)Man'''
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===Pterocarpus angolensis lectin (PAL) in complex with the trimannoside [Man(Alpha1-3)]Man(alpha1-6)Man===
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==Overview==
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The crystal structure of a Man/Glc-specific lectin from the seeds of the bloodwood tree (Pterocarpus angolensis), a leguminous plant from central Africa, has been determined in complex with mannose and five manno-oligosaccharides. The lectin contains a classical mannose-specificity loop, but its metal-binding loop resembles that of lectins of unrelated specificity from Ulex europaeus and Maackia amurensis. As a consequence, the interactions with mannose in the primary binding site are conserved, but details of carbohydrate-binding outside the primary binding site differ from those seen in the equivalent carbohydrate complexes of concanavalin A. These observations explain the differences in their respective fine specificity profiles for oligomannoses. While Man(alpha1-3)Man and Man(alpha1-3)[Man(alpha1-6)]Man bind to PAL in low-energy conformations identical with that of ConA, Man(alpha1-6)Man is required to adopt a different conformation. Man(alpha1-2)Man can bind only in a single binding mode, in sharp contrast to ConA, which creates a higher affinity for this disaccharide by allowing two binding modes.
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The line below this paragraph, {{ABSTRACT_PUBMED_14729339}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14729339 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14729339}}
==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Mannose]]
[[Category: Mannose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:43:20 2008''

Revision as of 21:43, 27 July 2008

Image:1q8v.png

Template:STRUCTURE 1q8v

Pterocarpus angolensis lectin (PAL) in complex with the trimannoside [Man(Alpha1-3)]Man(alpha1-6)Man

Template:ABSTRACT PUBMED 14729339

About this Structure

1Q8V is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.

Reference

Structural basis of oligomannose recognition by the Pterocarpus angolensis seed lectin., Loris R, Van Walle I, De Greve H, Beeckmans S, Deboeck F, Wyns L, Bouckaert J, J Mol Biol. 2004 Jan 30;335(5):1227-40. PMID:14729339

Page seeded by OCA on Mon Jul 28 00:43:20 2008

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