1pi1

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{{STRUCTURE_1pi1| PDB=1pi1 | SCENE= }}
{{STRUCTURE_1pi1| PDB=1pi1 | SCENE= }}
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'''Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.'''
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===Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.===
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==Overview==
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The Mob protein family comprises a group of highly conserved eukaryotic proteins whose founding member functions in the mitotic exit network. At the molecular level, Mob proteins act as kinase-activating subunits. We cloned a human Mob1 family member, Mob1A, and determined its three-dimensional structure by X-ray crystallography. The core of Mob1A consists of a four-helix bundle that is stabilized by a bound zinc atom. The N-terminal helix of the bundle is solvent exposed and together with adjacent secondary structure elements forms an evolutionarily conserved surface with a strong negative electrostatic potential. Several conditional mutant alleles of S. cerevisiae MOB1 target this surface and decrease its net negative charge. Interestingly, the kinases with which yeast Mob proteins interact have two conserved basic regions within their N-terminal lobe. Thus, Mob proteins may regulate their target kinases through electrostatic interactions mediated by conserved charged surfaces.
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(as it appears on PubMed at http://www.pubmed.gov), where 12962634 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12962634}}
==About this Structure==
==About this Structure==
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[[Category: Mitotic exit network]]
[[Category: Mitotic exit network]]
[[Category: Mob1]]
[[Category: Mob1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:06:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:45:10 2008''

Revision as of 21:45, 27 July 2008

Image:1pi1.png

Template:STRUCTURE 1pi1

Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.

Template:ABSTRACT PUBMED 12962634

About this Structure

1PI1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways., Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC, Structure. 2003 Sep;11(9):1163-70. PMID:12962634

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