1zlh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zlh.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1zlh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zlh| PDB=1zlh | SCENE= }}
{{STRUCTURE_1zlh| PDB=1zlh | SCENE= }}
-
'''Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase A'''
+
===Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase A===
-
==Overview==
+
<!--
-
The tick carboxypeptidase inhibitor (TCI) is a proteinaceous inhibitor of metallo-carboxypeptidases present in the blood-sucking tick Rhipicephalus bursa. The three-dimensional crystal structures of recombinant TCI bound to bovine carboxypeptidase A and to human carboxypeptidase B have been determined and refined at 1.7 A and at 2.0 A resolution, respectively. TCI consists of two domains that are structurally similar despite the low degree of sequence homology. The domains, each consisting of a short alpha-helix followed by a small twisted antiparallel beta-sheet, show a high level of structural homology to proteins of the beta-defensin-fold family. TCI anchors to the surface of mammalian carboxypeptidases in a double-headed manner not previously seen for carboxypeptidase inhibitors: the last three carboxy-terminal amino acid residues interact with the active site of the enzyme in a way that mimics substrate binding, and the N-terminal domain binds to an exosite distinct from the active-site groove. The structures of these complexes should prove valuable in the applications of TCI as a thrombolytic drug and as a basis for the design of novel bivalent carboxypeptidase inhibitors.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15961103}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15961103 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15961103}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode., Arolas JL, Popowicz GM, Lorenzo J, Sommerhoff CP, Huber R, Aviles FX, Holak TA, J Mol Biol. 2005 Jul 15;350(3):489-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15961103 15961103]
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode., Arolas JL, Popowicz GM, Lorenzo J, Sommerhoff CP, Huber R, Aviles FX, Holak TA, J Mol Biol. 2005 Jul 15;350(3):489-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15961103 15961103]
 +
 +
A carboxypeptidase inhibitor from the tick Rhipicephalus bursa: isolation, cDNA cloning, recombinant expression, and characterization., Arolas JL, Lorenzo J, Rovira A, Castella J, Aviles FX, Sommerhoff CP, J Biol Chem. 2005 Feb 4;280(5):3441-8. Epub 2004 Nov 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15561703 15561703]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Carboxypeptidase A]]
[[Category: Carboxypeptidase A]]
Line 32: Line 38:
[[Category: Sommerhoff, C P.]]
[[Category: Sommerhoff, C P.]]
[[Category: Inhibitor-metallocarboxypeptidase complex]]
[[Category: Inhibitor-metallocarboxypeptidase complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:46:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:46:19 2008''

Revision as of 21:46, 27 July 2008

Image:1zlh.png

Template:STRUCTURE 1zlh

Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase A

Template:ABSTRACT PUBMED 15961103

About this Structure

1ZLH is a Protein complex structure of sequences from Bos taurus and Rhipicephalus bursa. Full crystallographic information is available from OCA.

Reference

The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode., Arolas JL, Popowicz GM, Lorenzo J, Sommerhoff CP, Huber R, Aviles FX, Holak TA, J Mol Biol. 2005 Jul 15;350(3):489-98. PMID:15961103

A carboxypeptidase inhibitor from the tick Rhipicephalus bursa: isolation, cDNA cloning, recombinant expression, and characterization., Arolas JL, Lorenzo J, Rovira A, Castella J, Aviles FX, Sommerhoff CP, J Biol Chem. 2005 Feb 4;280(5):3441-8. Epub 2004 Nov 23. PMID:15561703

Page seeded by OCA on Mon Jul 28 00:46:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zlh"
Personal tools