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| - | [[Image:1uoh.gif|left|200px]] | + | {{Seed}} |
| | + | [[Image:1uoh.png|left|200px]] |
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| | {{STRUCTURE_1uoh| PDB=1uoh | SCENE= }} | | {{STRUCTURE_1uoh| PDB=1uoh | SCENE= }} |
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| - | '''HUMAN GANKYRIN'''
| + | ===HUMAN GANKYRIN=== |
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| - | ==Overview==
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| - | Gankyrin is a 25-kDa hepatocellular carcinoma-associated protein that mediates protein-protein interactions in cell cycle control and protein degradation. It has been reported to form complexes with cyclin-dependent kinase 4, retinoblastoma protein, the S6b ATPase subunit of the 19 S regulator of the 26 S proteasome, and Mdm2, an E3 ubiquitin ligase involved in p53 degradation. It is the first protein described to bind both to the 26 S proteasome and to proteins in other complexes containing cyclin-dependent kinase(s) and p53 ubiquitylating activities, thus providing a mechanism for delivering cell cycle regulating machinery and ubiquitylated substrates to the proteasome for degradation. Gankyrin contains a 33-residue motif known as the ankyrin repeat that occurs five and a half to six times in the sequence. As a step toward understanding gankyrin interactions with its protein partners we have determined its three-dimensional crystal structure to 2.0-A resolution. It reveals that the entire 226-residue gankyrin polypeptide folds into seven ankyrin repeat elements. The ankyrin repeats, consisting of an antiparallel beta-hairpin followed by a perpendicularly oriented helix-loop-helix, pack side-by-side, creating an extended curved structure with a groove running across the long concave surface. Comparison with the structures of other ankyrin repeat proteins suggests that interactions with partner proteins are mediated by residues situated on this concave surface.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_14573599}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 14573599 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_14573599}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Ankyrin repeat,26s proteasome]] | | [[Category: Ankyrin repeat,26s proteasome]] |
| | [[Category: Oncoprotein]] | | [[Category: Oncoprotein]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:30:00 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:50:38 2008'' |
Revision as of 21:50, 27 July 2008
Template:STRUCTURE 1uoh
HUMAN GANKYRIN
Template:ABSTRACT PUBMED 14573599
About this Structure
1UOH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53., Krzywda S, Brzozowski AM, Higashitsuji H, Fujita J, Welchman R, Dawson S, Mayer RJ, Wilkinson AJ, J Biol Chem. 2004 Jan 9;279(2):1541-5. Epub 2003 Oct 22. PMID:14573599
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