2i40

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[[Image:2i40.gif|left|200px]]
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{{STRUCTURE_2i40| PDB=2i40 | SCENE= }}
{{STRUCTURE_2i40| PDB=2i40 | SCENE= }}
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'''Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor'''
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===Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor===
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==Overview==
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The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-epsilon kinase is described. Compound 12e was identified with an IKK-epsilon enzyme potency of pIC(50) 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.
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(as it appears on PubMed at http://www.pubmed.gov), where 16997559 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16997559}}
==About this Structure==
==About this Structure==
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[[Category: Cyclin]]
[[Category: Cyclin]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:02:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:51:55 2008''

Revision as of 21:51, 27 July 2008

Template:STRUCTURE 2i40

Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor

Template:ABSTRACT PUBMED 16997559

About this Structure

2I40 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase., Bamborough P, Christopher JA, Cutler GJ, Dickson MC, Mellor GW, Morey JV, Patel CB, Shewchuk LM, Bioorg Med Chem Lett. 2006 Dec 15;16(24):6236-40. Epub 2006 Sep 25. PMID:16997559

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