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3c4w

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{{STRUCTURE_3c4w| PDB=3c4w | SCENE= }}
{{STRUCTURE_3c4w| PDB=3c4w | SCENE= }}
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'''Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A'''
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===Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A===
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==Overview==
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G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins. Here we report six crystal structures of rhodopsin kinase (GRK1), revealing not only three distinct nucleotide-binding states of a GRK but also two key structural elements believed to be involved in the recognition of activated GPCRs. The first is the C-terminal extension of the kinase domain, which was observed in all nucleotide-bound GRK1 structures. The second is residues 5-30 of the N terminus, observed in one of the GRK1.(Mg(2+))(2).ATP structures. The N terminus was also clearly phosphorylated, leading to the identification of two novel phosphorylation sites by mass spectral analysis. Co-localization of the N terminus and the C-terminal extension near the hinge of the kinase domain suggests that activated GPCRs stimulate kinase activity by binding to this region to facilitate full closure of the kinase domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 18339619 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18339619}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:36:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:53:55 2008''

Revision as of 21:54, 27 July 2008

Image:3c4w.png

Template:STRUCTURE 3c4w

Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.7A

Template:ABSTRACT PUBMED 18339619

About this Structure

3C4W is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation., Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ, J Biol Chem. 2008 May 16;283(20):14053-62. Epub 2008 Mar 13. PMID:18339619

Page seeded by OCA on Mon Jul 28 00:53:55 2008

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