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2f1c

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{{STRUCTURE_2f1c| PDB=2f1c | SCENE= }}
{{STRUCTURE_2f1c| PDB=2f1c | SCENE= }}
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'''Crystal structure of the monomeric porin OmpG'''
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===Crystal structure of the monomeric porin OmpG===
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==Overview==
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The outer membrane (OM) of Gram-negative bacteria contains a large number of channel proteins that mediate the uptake of ions and nutrients necessary for growth and functioning of the cell. An important group of OM channel proteins are the porins, which mediate the non-specific, diffusion-based passage of small (&lt;600 Da) polar molecules. All porins of Gram-negative bacteria that have been crystallized to date form stable trimers, with each monomer composed of a 16-stranded beta-barrel with a relatively narrow central pore. In contrast, the OmpG porin is unique, as it appears to function as a monomer. We have determined the X-ray crystal structure of OmpG from Escherichia coli to a resolution of 2.3 A. The structure shows a 14-stranded beta-barrel with a relatively simple architecture. Due to the absence of loops that fold back into the channel, OmpG has a large ( approximately 13 A) central pore that is considerably wider than those of other E. coli porins, and very similar in size to that of the toxin alpha-hemolysin. The architecture of the channel, together with previous biochemical and other data, suggests that OmpG may form a non-specific channel for the transport of larger oligosaccharides. The structure of OmpG provides the starting point for engineering studies aiming to generate selective channels and for the development of biosensors.
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(as it appears on PubMed at http://www.pubmed.gov), where 16797588 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16797588}}
==About this Structure==
==About this Structure==
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[[Category: Subbarao, G V.]]
[[Category: Subbarao, G V.]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:20:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:54:25 2008''

Revision as of 21:54, 27 July 2008

Image:2f1c.png

Template:STRUCTURE 2f1c

Crystal structure of the monomeric porin OmpG

Template:ABSTRACT PUBMED 16797588

About this Structure

2F1C is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the monomeric porin OmpG., Subbarao GV, van den Berg B, J Mol Biol. 2006 Jul 21;360(4):750-9. Epub 2006 Jun 2. PMID:16797588

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