2grh

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{{STRUCTURE_2grh| PDB=2grh | SCENE= }}
{{STRUCTURE_2grh| PDB=2grh | SCENE= }}
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'''M37V mutant of Scapharca dimeric hemoglobin, with CO bound'''
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===M37V mutant of Scapharca dimeric hemoglobin, with CO bound===
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==Overview==
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Protein allostery provides mechanisms for regulation of biological function at the molecular level. We present here an investigation of global, ligand-induced allosteric transition in a protein by time-resolved x-ray diffraction. The study provides a view of structural changes in single crystals of Scapharca dimeric hemoglobin as they proceed in real time, from 5 ns to 80 micros after ligand photodissociation. A tertiary intermediate structure forms rapidly (&lt;5 ns) as the protein responds to the presence of an unliganded heme within each R-state protein subunit, with key structural changes observed in the heme groups, neighboring residues, and interface water molecules. This intermediate lays a foundation for the concerted tertiary and quaternary structural changes that occur on a microsecond time scale and are associated with the transition to a low-affinity T-state structure. Reversal of these changes shows a considerable lag as a T-like structure persists well after ligand rebinding, suggesting a slow T-to-R transition.
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(as it appears on PubMed at http://www.pubmed.gov), where 16684887 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16684887}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen affinity]]
[[Category: Oxygen affinity]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:26:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:57:02 2008''

Revision as of 21:57, 27 July 2008

Image:2grh.png

Template:STRUCTURE 2grh

M37V mutant of Scapharca dimeric hemoglobin, with CO bound

Template:ABSTRACT PUBMED 16684887

About this Structure

2GRH is a Single protein structure of sequence from Scapharca inaequivalvis. Full crystallographic information is available from OCA.

Reference

Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin., Knapp JE, Pahl R, Srajer V, Royer WE Jr, Proc Natl Acad Sci U S A. 2006 May 16;103(20):7649-54. Epub 2006 May 9. PMID:16684887

Page seeded by OCA on Mon Jul 28 00:57:02 2008

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