2alj

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[[Image:2alj.gif|left|200px]]
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[[Image:2alj.png|left|200px]]
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{{STRUCTURE_2alj| PDB=2alj | SCENE= }}
{{STRUCTURE_2alj| PDB=2alj | SCENE= }}
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'''Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus'''
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===Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus===
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==Overview==
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Bacterial cytokinesis requires the coordinated assembly of a complex of proteins, collectively known as the divisome, at the incipient division site. DivIB/FtsQ is a conserved component of the divisome in bacteria with cell walls, suggesting that it plays a role in synthesis and/or remodeling of septal peptidoglycan. We demonstrate that the extracytoplasmic region of DivIB comprises three discrete domains that we designate alpha, beta, and gamma from the N to C terminus. The alpha-domain is proximal to the cytoplasmic membrane and coincident with the polypeptide transport-associated domain that was proposed previously to function as a molecular chaperone. The beta-domain has a unique 3D fold, with no eukaryotic counterpart, and we show that it interconverts between two discrete conformations via cis-trans isomerization of a Tyr-Pro peptide bond. We propose that this isomerization might modulate protein-protein interactions of the flanking alpha- and gamma-domains. The C-terminal gamma-domain is unstructured in the absence of other divisomal proteins, but we show that it is critical for DivIB function.
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The line below this paragraph, {{ABSTRACT_PUBMED_16618922}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16618922 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16618922}}
==About this Structure==
==About this Structure==
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2ALJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALJ OCA].
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2ALJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALJ OCA].
==Reference==
==Reference==
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[[Category: Divisome]]
[[Category: Divisome]]
[[Category: Ftsq]]
[[Category: Ftsq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:11:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:59:36 2008''

Revision as of 21:59, 27 July 2008

Image:2alj.png

Template:STRUCTURE 2alj

Structure of the cis confomer of the major extracytoplasmic domain of the bacterial cell division protein divib from geobacillus stearothermophilus

Template:ABSTRACT PUBMED 16618922

About this Structure

2ALJ is a Single protein structure of sequence from Geobacillus stearothermophilus. Full experimental information is available from OCA.

Reference

Domain architecture and structure of the bacterial cell division protein DivIB., Robson SA, King GF, Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6700-5. Epub 2006 Apr 17. PMID:16618922

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