1kzq
From Proteopedia
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(New page: 200px<br /><applet load="1kzq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kzq, resolution 1.7Å" /> '''crystal structure of ...)
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Revision as of 17:59, 20 November 2007
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crystal structure of a parasite protein
Overview
Toxoplasma gondii is a persistent protozoan parasite capable of infecting, almost any warm-blooded vertebrate. The surface of Toxoplasma is coated, with a family of developmentally regulated glycosylphosphatidylinositol, (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS, proteins mediate attachment to host cells and interface with the host, immune response to regulate the virulence of the parasite. The 1.7 A, structure of the immunodominant SAG1 antigen reveals a homodimeric, configuration in which the dimeric interface is mediated by an extended, beta-sheet that forms a deep groove lined with positively charged amino, acids. This basic groove seems to be conserved among SRS proteins and, potentially serves as a sulfated proteoglycan-binding site on target cell, surfaces, thus rationalizing the promiscuous attachment properties of, Toxoplasma to a broad range of host cell types.
About this Structure
1KZQ is a Single protein structure of sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.
Reference
Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily., He XL, Grigg ME, Boothroyd JC, Garcia KC, Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:12091874
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