1rru

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[[Image:1rru.gif|left|200px]]
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{{STRUCTURE_1rru| PDB=1rru | SCENE= }}
{{STRUCTURE_1rru| PDB=1rru | SCENE= }}
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'''The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals'''
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===The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals===
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==Overview==
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The X-ray structure of a self-complementary PNA hexamer (H-CGTACG-L-Lys-NH(2)) has been determined to 2.35 A resolution. The introduction of an L-lysine moiety has previously been shown to induce a preferred left-handedness of the PNA double helices in aqueous solution. However, in the crystal structure an equal amount of interchanging right- and left-handed helices is observed. The lysine moieties are pointing into large solvent channels and no significant interactions between this moiety and the remaining PNA molecule are observed. In contrast, molecular mechanics calculations show a preference for the left-handed helix of this hexameric PNA in aqueous solution as expected. The calculations indicate that the difference in the free energy of solvation between the left-handed and the right-handed helix is the determining factor for the preference of the left-handed helix in aqueous solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 14692794 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14692794}}
==About this Structure==
==About this Structure==
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[[Category: Pna]]
[[Category: Pna]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:50:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:16:44 2008''

Revision as of 22:16, 27 July 2008

Image:1rru.png

Template:STRUCTURE 1rru

The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals

Template:ABSTRACT PUBMED 14692794

About this Structure

Full crystallographic information is available from OCA.

Reference

The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals., Rasmussen H, Liljefors T, Petersson B, Nielsen PE, Liljefors T, Kastrup JS, J Biomol Struct Dyn. 2004 Feb;21(4):495-502. PMID:14692794

Page seeded by OCA on Mon Jul 28 01:16:44 2008

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