1wrm

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{{STRUCTURE_1wrm| PDB=1wrm | SCENE= }}
{{STRUCTURE_1wrm| PDB=1wrm | SCENE= }}
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'''Crystal structure of JSP-1'''
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===Crystal structure of JSP-1===
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==Overview==
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Human JNK stimulatory phosphatase-1 (JSP-1) is a novel member of dual specificity phosphatases. A C-terminus truncated JSP-1 was expressed in Escherichia coli and was crystallized using the sitting-drop vapor diffusion method. Thin-plate crystals obtained at 278 K belong to a monoclinic space group, C2, with unit-cell parameters a = 84.0 A, b = 49.3 A, c = 47.3 A, and beta = 119.5 degrees , and diffract up to 1.5 A resolution at 100 K. The structure of JSP-1 has a single compact (alpha/beta) domain, which consists of six alpha-helices and five beta-strands, and shows a conserved structural scaffold in regard to both DSPs and PTPs. A cleft formed by a PTP-loop at the active site is very shallow, and is occupied by one sulfonate compound, MES, at the bottom. In the binary complex structure of JSP-1 with MES, the conformations of three important segments in regard to the catalytic mechanism are not similar to those in PTP1B. JSP-1 has no loop corresponding to the Lys120-loop of PTP1B, and tryptophan residue corresponding to the substrate-stacking in PTP1B is substituted by alanine residue in JSP-1.
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(as it appears on PubMed at http://www.pubmed.gov), where 17068812 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17068812}}
==About this Structure==
==About this Structure==
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[[Category: Jnk]]
[[Category: Jnk]]
[[Category: Phosphatase]]
[[Category: Phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:03:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:29:17 2008''

Revision as of 22:29, 27 July 2008

Image:1wrm.png

Template:STRUCTURE 1wrm

Crystal structure of JSP-1

Template:ABSTRACT PUBMED 17068812

About this Structure

1WRM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution., Yokota T, Nara Y, Kashima A, Matsubara K, Misawa S, Kato R, Sugio S, Proteins. 2007 Feb 1;66(2):272-8. PMID:17068812

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