2g94

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{{STRUCTURE_2g94| PDB=2g94 | SCENE= }}
{{STRUCTURE_2g94| PDB=2g94 | SCENE= }}
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'''Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.'''
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===Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.===
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==Overview==
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Structure-based design, synthesis, and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors are designed specifically to interact with S2- and S3-active site residues to provide selectivity over memapsin 1 and cathepsin D. Inhibitor 6 has exhibited exceedingly potent inhibitory activity against memapsin 2 and selectivity over memapsin 1 (&gt;3800-fold) and cathepsin D (&gt;2500-fold). A protein-ligand crystal structure revealed cooperative interactions in the S2- and S3-active sites of memapsin 2. These interactions may serve as an important guide to design selectivity over memapsin 1 and cathepsin D.
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(as it appears on PubMed at http://www.pubmed.gov), where 16620080 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16620080}}
==About this Structure==
==About this Structure==
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[[Category: Memapsin]]
[[Category: Memapsin]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:50:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:33:08 2008''

Revision as of 22:33, 27 July 2008

Image:2g94.png

Template:STRUCTURE 2g94

Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.

Template:ABSTRACT PUBMED 16620080

About this Structure

2G94 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors., Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J, J Am Chem Soc. 2006 Apr 26;128(16):5310-1. PMID:16620080

Page seeded by OCA on Mon Jul 28 01:33:08 2008

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