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3c0i

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{{STRUCTURE_3c0i| PDB=3c0i | SCENE= }}
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'''CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form'''
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===CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form===
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==Overview==
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CASK is a unique MAGUK protein that contains an N-terminal CaM-kinase domain besides the typical MAGUK domains. The CASK CaM-kinase domain is presumed to be a catalytically inactive pseudokinase because it lacks the canonical DFG motif required for Mg2+ binding that is thought to be indispensable for kinase activity. Here we show, however, that CASK functions as an active protein kinase even without Mg2+ binding. High-resolution crystal structures reveal that the CASK CaM-kinase domain adopts a constitutively active conformation that binds ATP and catalyzes phosphotransfer without Mg2+. The CASK CaM-kinase domain phosphorylates itself and at least one physiological interactor, the synaptic protein neurexin-1, to which CASK is recruited via its PDZ domain. Thus, our data indicate that CASK combines the scaffolding activity of MAGUKs with an unusual kinase activity that phosphorylates substrates recuited by the scaffolding activity. Moreover, our study suggests that other pseudokinases (10% of the kinome) could also be catalytically active.
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==About this Structure==
==About this Structure==
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[[Category: Synaptic plasticity]]
[[Category: Synaptic plasticity]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:35:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:41:02 2008''

Revision as of 22:41, 27 July 2008

Image:3c0i.png

Template:STRUCTURE 3c0i

CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form

Template:ABSTRACT PUBMED 18423203

About this Structure

3C0I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

CASK Functions as a Mg2+-independent neurexin kinase., Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Sudhof TC, Wahl MC, Cell. 2008 Apr 18;133(2):328-39. PMID:18423203

Page seeded by OCA on Mon Jul 28 01:41:02 2008

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