2dxs

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{{STRUCTURE_2dxs| PDB=2dxs | SCENE= }}
{{STRUCTURE_2dxs| PDB=2dxs | SCENE= }}
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'''Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor'''
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===Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor===
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==Overview==
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We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing a basic pendent group with high biochemical and cellular potencies. These compounds displayed a very small shift in cellular potency when the replicon assay was performed in the presence of human serum albumin.
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{{ABSTRACT_PUBMED_17125247}}
==About this Structure==
==About this Structure==
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[[Category: Ns5b]]
[[Category: Ns5b]]
[[Category: Rna polymerase]]
[[Category: Rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:35:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:42:30 2008''

Revision as of 22:42, 27 July 2008

Template:STRUCTURE 2dxs

Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor

Template:ABSTRACT PUBMED 17125247

About this Structure

2DXS is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors., Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H, J Med Chem. 2006 Nov 30;49(24):6950-3. PMID:17125247

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