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1r5t

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{{STRUCTURE_1r5t| PDB=1r5t | SCENE= }}
{{STRUCTURE_1r5t| PDB=1r5t | SCENE= }}
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'''The Crystal Structure of Cytidine Deaminase CDD1, an Orphan C to U editase from Yeast'''
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===The Crystal Structure of Cytidine Deaminase CDD1, an Orphan C to U editase from Yeast===
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==Overview==
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Activation-induced deaminase (AID) uses base deamination for class-switch recombination and somatic hypermutation and is related to the mammalian RNA-editing enzyme apolipoprotein B editing catalytic subunit 1 (APOBEC-1). CDD1 is a yeast ortholog of APOBEC-1 that exhibits cytidine deaminase and RNA-editing activity. Here, we present the crystal structure of CDD1 at 2.0-A resolution and its use in comparative modeling of APOBEC-1 and AID. The models explain dimerization and the need for trans-acting loops that contribute to active site formation. Substrate selectivity appears to be regulated by a central active site "flap" whose size and flexibility accommodate large substrates in contrast to deaminases of pyrimidine metabolism that bind only small nucleosides or free bases. Most importantly, the results suggested both AID and APOBEC-1 are equally likely to bind single-stranded DNA or RNA, which has implications for the identification of natural AID targets.
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(as it appears on PubMed at http://www.pubmed.gov), where 15148397 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15148397}}
==About this Structure==
==About this Structure==
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[[Category: Rna editing]]
[[Category: Rna editing]]
[[Category: Zinc dependent deaminase]]
[[Category: Zinc dependent deaminase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:06:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:54:56 2008''

Revision as of 22:54, 27 July 2008

Image:1r5t.png

Template:STRUCTURE 1r5t

The Crystal Structure of Cytidine Deaminase CDD1, an Orphan C to U editase from Yeast

Template:ABSTRACT PUBMED 15148397

About this Structure

1R5T is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1., Xie K, Sowden MP, Dance GS, Torelli AT, Smith HC, Wedekind JE, Proc Natl Acad Sci U S A. 2004 May 25;101(21):8114-9. Epub 2004 May 17. PMID:15148397

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