This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1u0u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1u0u.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1u0u.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1u0u| PDB=1u0u | SCENE= }}
{{STRUCTURE_1u0u| PDB=1u0u | SCENE= }}
-
'''An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: Pine stilbene synthase structure'''
+
===An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: Pine stilbene synthase structure===
-
==Overview==
+
<!--
-
Stilbene synthase (STS) and chalcone synthase (CHS) each catalyze the formation of a tetraketide intermediate from a CoA-tethered phenylpropanoid starter and three molecules of malonyl-CoA, but use different cyclization mechanisms to produce distinct chemical scaffolds for a variety of plant natural products. Here we present the first STS crystal structure and identify, by mutagenic conversion of alfalfa CHS into a functional stilbene synthase, the structural basis for the evolution of STS cyclization specificity in type III polyketide synthase (PKS) enzymes. Additional mutagenesis and enzymatic characterization confirms that electronic effects rather than steric factors balance competing cyclization specificities in CHS and STS. Finally, we discuss the problematic in vitro reconstitution of plant stilbenecarboxylate pathways, using insights from existing biomimetic polyketide cyclization studies to generate a novel mechanistic hypothesis to explain stilbenecarboxylate biosynthesis.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15380179}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15380179 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15380179}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Thiolase fold]]
[[Category: Thiolase fold]]
[[Category: Type iii polyketide synthase]]
[[Category: Type iii polyketide synthase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:36:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:59:15 2008''

Revision as of 22:59, 27 July 2008

Image:1u0u.png

Template:STRUCTURE 1u0u

An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: Pine stilbene synthase structure

Template:ABSTRACT PUBMED 15380179

About this Structure

1U0U is a Single protein structure of sequence from Pinus sylvestris. Full crystallographic information is available from OCA.

Reference

An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases., Austin MB, Bowman ME, Ferrer JL, Schroder J, Noel JP, Chem Biol. 2004 Sep;11(9):1179-94. PMID:15380179

Page seeded by OCA on Mon Jul 28 01:59:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u0u"
Personal tools