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2fw4

From Proteopedia

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[[Image:2fw4.gif|left|200px]]
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{{STRUCTURE_2fw4| PDB=2fw4 | SCENE= }}
{{STRUCTURE_2fw4| PDB=2fw4 | SCENE= }}
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'''Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.'''
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===Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.===
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==Overview==
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The X-ray crystallographic structure for the adduct of an activator with human carbonic anhydrase isozyme I (hCA I) is reported. L-Histidine binds deep within the enzyme active site, participating in a network of hydrogen bonds involving its carboxylate moiety and the zinc-bound water molecule, as well as the imidazole of His200, being in van der Waals contacts with Thr199, His200, His64, and His67. This binding is very different from that to the other major cytosolic isozyme hCA II.
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(as it appears on PubMed at http://www.pubmed.gov), where 16870440 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16870440}}
==About this Structure==
==About this Structure==
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[[Category: Carbonic anhydrase i]]
[[Category: Carbonic anhydrase i]]
[[Category: Crystal structure]]
[[Category: Crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:22:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:00:57 2008''

Revision as of 23:00, 27 July 2008

Image:2fw4.png

Template:STRUCTURE 2fw4

Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.

Template:ABSTRACT PUBMED 16870440

About this Structure

2FW4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I., Temperini C, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:16870440

Page seeded by OCA on Mon Jul 28 02:00:57 2008

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