2b9i

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{{STRUCTURE_2b9i| PDB=2b9i | SCENE= }}
{{STRUCTURE_2b9i| PDB=2b9i | SCENE= }}
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'''Crystal structure of Fus3 with a docking motif from Msg5'''
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===Crystal structure of Fus3 with a docking motif from Msg5===
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==Overview==
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Cells use a network of mitogen-activated protein kinases (MAPKs) to coordinate responses to diverse extracellular signals. Here, we examine the role of docking interactions in determining connectivity of the yeast MAPKs Fus3 and Kss1. These closely related kinases are activated by the common upstream MAPK kinase Ste7 yet generate distinct output responses, mating and filamentous growth, respectively. We find that docking interactions are necessary for communication with the kinases and that they can encode subtle differences in pathway-specific input and output. The cell cycle arrest mediator Far1, a mating-specific substrate, has a docking motif that selectively binds Fus3. In contrast, the shared partner Ste7 has a promiscuous motif that binds both Fus3 and Kss1. Structural analysis reveals that Fus3 interacts with specific and promiscuous peptides in conformationally distinct modes. Induced fit recognition may allow docking peptides to achieve discrimination by exploiting subtle differences in kinase flexibility.
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(as it appears on PubMed at http://www.pubmed.gov), where 16364919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16364919}}
==About this Structure==
==About this Structure==
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[[Category: Remenyi, A.]]
[[Category: Remenyi, A.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:01:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:01:24 2008''

Revision as of 23:01, 27 July 2008

Image:2b9i.png

Template:STRUCTURE 2b9i

Crystal structure of Fus3 with a docking motif from Msg5

Template:ABSTRACT PUBMED 16364919

About this Structure

2B9I is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network., Remenyi A, Good MC, Bhattacharyya RP, Lim WA, Mol Cell. 2005 Dec 22;20(6):951-62. PMID:16364919

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