1s4i

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{{STRUCTURE_1s4i| PDB=1s4i | SCENE= }}
{{STRUCTURE_1s4i| PDB=1s4i | SCENE= }}
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'''Crystal structure of a SOD-like protein from Bacillus subtilis'''
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===Crystal structure of a SOD-like protein from Bacillus subtilis===
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==Overview==
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Little is known about prokaryotic homologs of Cu,Zn superoxide dismutase (SOD), an enzyme highly conserved among eukaryotic species. In 138 Archaea and Bacteria genomes, 57 of these putative homologs were found, 11 of which lack at least one of the metal ligands. Both the solution and the crystal structures of the SOD-like protein from Bacillus subtilis, lacking two Cu ligands and found to be enzymatically inactive, were determined. In solution, the protein is monomeric. The available nuclear Overhauser effects, together with chemical-shift index values, allowed us to define and to recognize the typical Cu,Zn SOD Greek beta-barrel but with largely unstructured loops (which, therefore, sample a wide range of conformations). On the contrary, in the crystal structure (obtained in the presence of slight excess of Zn), the protein is well structured and organized in covalent dimers held by a symmetric bridge consisting of a Zn ion bound to an Asp-His dyad in a tetrahedral geometry. Couples of dimers held by hydrophobic interactions and H bonds are further organized in long chains. The order/disorder transition is discussed in terms of metal binding and physical state.
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The line below this paragraph, {{ABSTRACT_PUBMED_15897454}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15897454 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15897454}}
==About this Structure==
==About this Structure==
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[[Category: Sod-like]]
[[Category: Sod-like]]
[[Category: Superoxide dismutase]]
[[Category: Superoxide dismutase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:17:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:08:30 2008''

Revision as of 23:08, 27 July 2008

Image:1s4i.png

Template:STRUCTURE 1s4i

Crystal structure of a SOD-like protein from Bacillus subtilis

Template:ABSTRACT PUBMED 15897454

About this Structure

1S4I is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

A prokaryotic superoxide dismutase paralog lacking two Cu ligands: from largely unstructured in solution to ordered in the crystal., Banci L, Bertini I, Calderone V, Cramaro F, Del Conte R, Fantoni A, Mangani S, Quattrone A, Viezzoli MS, Proc Natl Acad Sci U S A. 2005 May 24;102(21):7541-6. Epub 2005 May 16. PMID:15897454

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