1y7n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1y7n.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1y7n.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1y7n| PDB=1y7n | SCENE= }}
{{STRUCTURE_1y7n| PDB=1y7n | SCENE= }}
-
'''Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha'''
+
===Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha===
-
==Overview==
+
<!--
-
Protection against reactive oxygen species is provided by the copper containing enzyme superoxide dismutase 1 (SOD1). The copper chaperone CCS is responsible for copper insertion into apo-SOD1. This role is impaired by an interaction between the second PDZ domain (PDZ2alpha) of the neuronal adaptor protein X11alpha and the third domain of CCS (McLoughlin et al. (2001) J. Biol. Chem., 276, 9303-9307). The solution structure of the PDZ2alpha domain has been determined and the interaction with peptides derived from CCS has been explored. PDZ2alpha binds to the last four amino acids of the CCS protein (PAHL) with a dissociation constant of 91 +/- 2 microM. Peptide variants have been used to map the interaction areas on PDZ2alpha for each amino acid, showing an important role for the C-terminal leucine, in line with canonical PDZ-peptide interactions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16132821}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16132821 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16132821}}
==About this Structure==
==About this Structure==
-
1Y7N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7N OCA].
+
1Y7N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7N OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: Copper chaperone for superoxide dismutase]]
[[Category: Copper chaperone for superoxide dismutase]]
[[Category: Neuronal adaptor]]
[[Category: Neuronal adaptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:58:11 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:08:36 2008''

Revision as of 23:08, 27 July 2008

Image:1y7n.png

Template:STRUCTURE 1y7n

Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha

Template:ABSTRACT PUBMED 16132821

About this Structure

1Y7N is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase., Duquesne AE, Ruijter M, Brouwer J, Drijfhout JW, Nabuurs SB, Spronk CA, Vuister GW, Ubbink M, Canters GW, J Biomol NMR. 2005 Jul;32(3):209-18. PMID:16132821

Page seeded by OCA on Mon Jul 28 02:08:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y7n"
Personal tools