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1qjm

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[[Image:1qjm.gif|left|200px]]
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{{STRUCTURE_1qjm| PDB=1qjm | SCENE= }}
{{STRUCTURE_1qjm| PDB=1qjm | SCENE= }}
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'''CRYSTAL STRUCTURE OF A COMPLEX OF LACTOFERRIN WITH A LANTHANIDE ION (SM3+) AT 3.4 ANSTROM RESOLUTION'''
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===CRYSTAL STRUCTURE OF A COMPLEX OF LACTOFERRIN WITH A LANTHANIDE ION (SM3+) AT 3.4 ANSTROM RESOLUTION===
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==Overview==
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Lactoferrin is an important member of the transferrin family. A characteristic property of transferrins is their ability to bind very tightly (K(app) approximately/= 10(20)) but reversibly two Fe(3+) ions. The structural consequences of binding a metal other than Fe(3+) have been examined by crystallographic analysis at 3.4 A resolution of mare samarium-lactoferrin (Sm(2)Lf). The structure was refined to an R factor of 0.219 for 8776 reflections in the resolution range 17.0-3.4 A. The samarium geometry (distorted octahedral coordination) is similar in both lobes. However, the anion interactions are quite different in the two lobes. In the N lobe, the anion is able to form only two hydrogen bonds instead of the four observed in the C lobe of Sm(2)Lf and the six observed in Fe(2)Lf. This is because Arg121, Thr117 and Gly124 have moved away from the anion as a consequence of the binding of the Sm(3+) ion. The protein ligands in the binding cleft of Sm(2)Lf show large displacements, but the overall protein structure remains the same. The binding of Sm(3+) by lactoferrin shows that the protein is capable of sequestering ions of different sizes and charges, though with reduced affinity. This conclusion should be true of other transferrins also.
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(as it appears on PubMed at http://www.pubmed.gov), where 10531475 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10531475}}
==About this Structure==
==About this Structure==
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[[Category: Lactoferrin]]
[[Category: Lactoferrin]]
[[Category: Transferrin]]
[[Category: Transferrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:21:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:08:54 2008''

Revision as of 23:09, 27 July 2008

Image:1qjm.png

Template:STRUCTURE 1qjm

CRYSTAL STRUCTURE OF A COMPLEX OF LACTOFERRIN WITH A LANTHANIDE ION (SM3+) AT 3.4 ANSTROM RESOLUTION

Template:ABSTRACT PUBMED 10531475

About this Structure

1QJM is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

Lactoferrin-metal interactions: first crystal structure of a complex of lactoferrin with a lanthanide ion (Sm3+) at 3.4 A resolution., Sharma AK, Singh TP, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1799-804. PMID:10531475

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