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244d

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{{STRUCTURE_244d| PDB=244d | SCENE= }}
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'''THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX'''
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===THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX===
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==Overview==
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Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
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(as it appears on PubMed at http://www.pubmed.gov), where 8036494 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8036494}}
==About this Structure==
==About this Structure==
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[[Category: Quadruple helix]]
[[Category: Quadruple helix]]
[[Category: Unusual dna]]
[[Category: Unusual dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:22:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:09:27 2008''

Revision as of 23:09, 27 July 2008

Image:244d.png

Template:STRUCTURE 244d

THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX

Template:ABSTRACT PUBMED 8036494

About this Structure

Full crystallographic information is available from OCA.

Reference

The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:8036494

Page seeded by OCA on Mon Jul 28 02:09:27 2008

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