1u89

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[[Image:1u89.gif|left|200px]]
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{{STRUCTURE_1u89| PDB=1u89 | SCENE= }}
{{STRUCTURE_1u89| PDB=1u89 | SCENE= }}
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'''Solution structure of VBS2 fragment of talin'''
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===Solution structure of VBS2 fragment of talin===
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==Overview==
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The cytoskeletal protein talin plays a key role in activating integrins and in coupling them to the actin cytoskeleton. Its N-terminal globular head, which binds beta integrins, is linked to an extended rod having a C-terminal actin binding site and several vinculin binding sites (VBSs). The NMR structure of residues 755-889 of the rod (containing a VBS) is shown to be an amphipathic four-helix bundle with a left-handed topology. A talin peptide corresponding to the VBS binds the vinculin head; the X-ray crystallographic structure of this complex shows that the residues which interact with vinculin are buried in the hydrophobic core of the talin fragment. NMR shows that the interaction involves a major structural change in the talin fragment, including unfolding of one of its helices, making the VBS accessible to vinculin. Interestingly, the talin 755-889 fragment binds more than one vinculin head molecule, suggesting that the talin rod may contain additional as yet unrecognized VBSs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15642262 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15642262}}
==About this Structure==
==About this Structure==
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1U89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U89 OCA].
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1U89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U89 OCA].
==Reference==
==Reference==
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[[Category: 4-helix bundle]]
[[Category: 4-helix bundle]]
[[Category: Left-handed]]
[[Category: Left-handed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:09:32 2008''

Revision as of 23:09, 27 July 2008

Image:1u89.png

Template:STRUCTURE 1u89

Solution structure of VBS2 fragment of talin

Template:ABSTRACT PUBMED 15642262

About this Structure

1U89 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head., Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL, Structure. 2005 Jan;13(1):65-74. PMID:15642262

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