1l2n
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(New page: 200px<br /><applet load="1l2n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l2n" /> '''Smt3 Solution Structure'''<br /> ==Overview...)
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Revision as of 18:04, 20 November 2007
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Smt3 Solution Structure
Overview
Smt3 belongs to a growing family of ubiquitin-related proteins involved in, posttranslational protein modification. Independent studies demonstrate an, essential function of Smt3 in the regulation of nucleocytoplasmic, transport, and suggest a role in cell-cycle regulation. Here we report the, high-resolution NMR structure of yeast Smt3 in the complex free form. Our, comparison of the Smt3 NMR structure with the Smt3 crystal structure in, complex with the C-Terminal Ulp1 protease domain revealed large structural, differences in the binding surface, which is also involved in the, Smt3-Ubc-9 interaction detected by NMR. The structural differences in the, region indicate the important functions of conserved residues in less, structurally defined sequences.
About this Structure
1L2N is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions., Sheng W, Liao X, Protein Sci. 2002 Jun;11(6):1482-91. PMID:12021447
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