1vzv

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{{STRUCTURE_1vzv| PDB=1vzv | SCENE= }}
{{STRUCTURE_1vzv| PDB=1vzv | SCENE= }}
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'''STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE'''
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===STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE===
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==Overview==
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Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides further evidence to support the finding that herpes virus proteases have a fold and active site distinct from other serine proteases. The VZV protease catalytic triad consists of a serine and two histidines. The distal histidine is proposed to properly orient the proximal histidine. The identification of an alpha-helical segment in the VZV protease that was mostly disordered in the CMV protease provides a better definition of the postulated active site cavity and reveals an elastase-like S' region. Structural differences between the VZV and CMV proteases also suggest potential differences in their oligomerization states.
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The line below this paragraph, {{ABSTRACT_PUBMED_9096314}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9096314 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9096314}}
==About this Structure==
==About this Structure==
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[[Category: Varicella-zoster virus]]
[[Category: Varicella-zoster virus]]
[[Category: Viral protease]]
[[Category: Viral protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:58:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:11:47 2008''

Revision as of 23:11, 27 July 2008

Image:1vzv.png

Template:STRUCTURE 1vzv

STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE

Template:ABSTRACT PUBMED 9096314

About this Structure

1VZV is a Single protein structure of sequence from Varicella-zoster virus (isolate 40a2). Full crystallographic information is available from OCA.

Reference

Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:9096314

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