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1qcv

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[[Image:1qcv.jpg|left|200px]]
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{{Seed}}
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[[Image:1qcv.png|left|200px]]
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{{STRUCTURE_1qcv| PDB=1qcv | SCENE= }}
{{STRUCTURE_1qcv| PDB=1qcv | SCENE= }}
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'''RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON'''
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===RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON===
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==Overview==
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The role of surface salt bridges in protein stabilization has been a source of controversy. Here we present the NMR structure of a hyperthermophilic rubredoxin variant (PFRD-XC4) and the thermodynamic analysis of two surface salt bridges by double mutant cycles. This analysis shows that the surface side chain to side chain salt bridge between Lys 6 and Glu 49 does not stabilize PFRD-XC4. The main chain to side chain salt bridge between the N-terminus and Glu 14 was, however, found to stabilize PFRD-XC4 by 1. 5 kcal mol(-)(1). The entropic cost of making a surface salt bridge involving the protein's backbone is reduced, since the backbone has already been immobilized upon protein folding.
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The line below this paragraph, {{ABSTRACT_PUBMED_10684603}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10684603 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10684603}}
==About this Structure==
==About this Structure==
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1QCV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCV OCA].
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1QCV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCV OCA].
==Reference==
==Reference==
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[[Category: Hyperthermophile]]
[[Category: Hyperthermophile]]
[[Category: Rubredoxin]]
[[Category: Rubredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:08:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:16:32 2008''

Revision as of 23:16, 27 July 2008

Image:1qcv.png

Template:STRUCTURE 1qcv

RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON

Template:ABSTRACT PUBMED 10684603

About this Structure

1QCV is a Single protein structure of sequence from Pyrococcus furiosus. Full experimental information is available from OCA.

Reference

Contribution of surface salt bridges to protein stability., Strop P, Mayo SL, Biochemistry. 2000 Feb 15;39(6):1251-5. PMID:10684603

Page seeded by OCA on Mon Jul 28 02:16:32 2008

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