1xp5

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[[Image:1xp5.gif|left|200px]]
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{{Seed}}
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[[Image:1xp5.png|left|200px]]
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{{STRUCTURE_1xp5| PDB=1xp5 | SCENE= }}
{{STRUCTURE_1xp5| PDB=1xp5 | SCENE= }}
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'''Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form'''
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===Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form===
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==Overview==
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P-type ATPases extract energy by hydrolysis of adenosine triphosphate (ATP) in two steps, formation and breakdown of a covalent phosphoenzyme intermediate. This process drives active transport and countertransport of the cation pumps. We have determined the crystal structure of rabbit sarcoplasmic reticulum Ca2+ adenosine triphosphatase in complex with aluminum fluoride, which mimics the transition state of hydrolysis of the counterion-bound (protonated) phosphoenzyme. On the basis of structural analysis and biochemical data, we find this form to represent an occluded state of the proton counterions. Hydrolysis is catalyzed by the conserved Thr-Gly-Glu-Ser motif, and it exploits an associative nucleophilic reaction mechanism of the same type as phosphoryl transfer from ATP. On this basis, we propose a general mechanism of occluded transition states of Ca2+ transport and H+ countertransport coupled to phosphorylation and dephosphorylation, respectively.
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The line below this paragraph, {{ABSTRACT_PUBMED_15618517}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15618517 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15618517}}
==About this Structure==
==About this Structure==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: P-type atpase]]
[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:19:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:19:08 2008''

Revision as of 23:19, 27 July 2008

Image:1xp5.png

Template:STRUCTURE 1xp5

Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form

Template:ABSTRACT PUBMED 15618517

About this Structure

1XP5 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Dephosphorylation of the calcium pump coupled to counterion occlusion., Olesen C, Sorensen TL, Nielsen RC, Moller JV, Nissen P, Science. 2004 Dec 24;306(5705):2251-5. PMID:15618517

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