2owo

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[[Image:2owo.gif|left|200px]]
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[[Image:2owo.png|left|200px]]
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{{STRUCTURE_2owo| PDB=2owo | SCENE= }}
{{STRUCTURE_2owo| PDB=2owo | SCENE= }}
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'''Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate'''
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===Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate===
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==Overview==
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NAD(+)-dependent DNA ligases (LigA) are ubiquitous in bacteria and essential for growth. Their distinctive substrate specificity and domain organization vis-a-vis human ATP-dependent ligases make them outstanding targets for anti-infective drug discovery. We report here the 2.3 A crystal structure of Escherichia coli LigA bound to an adenylylated nick, which captures LigA in a state poised for strand closure and reveals the basis for nick recognition. LigA envelopes the DNA within a protein clamp. Large protein domain movements and remodeling of the active site orchestrate progression through the three chemical steps of the ligation reaction. The structure inspires a strategy for inhibitor design.
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(as it appears on PubMed at http://www.pubmed.gov), where 17466627 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17466627}}
==About this Structure==
==About this Structure==
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[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Protein/dna complex]]
[[Category: Protein/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:49:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:22:01 2008''

Revision as of 23:22, 27 July 2008

Image:2owo.png

Template:STRUCTURE 2owo

Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate

Template:ABSTRACT PUBMED 17466627

About this Structure

2OWO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate., Nandakumar J, Nair PA, Shuman S, Mol Cell. 2007 Apr 27;26(2):257-71. PMID:17466627

Page seeded by OCA on Mon Jul 28 02:22:01 2008

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