1jwe

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{{STRUCTURE_1jwe| PDB=1jwe | SCENE= }}
{{STRUCTURE_1jwe| PDB=1jwe | SCENE= }}
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'''NMR Structure of the N-Terminal Domain of E. Coli Dnab Helicase'''
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===NMR Structure of the N-Terminal Domain of E. Coli Dnab Helicase===
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==Overview==
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BACKGROUND: DnaB is the primary replicative helicase in Escherichia coli. Native DnaB is a hexamer of identical subunits, each consisting of a larger C-terminal domain and a smaller N-terminal domain. Electron-microscopy data show hexamers with C6 or C3 symmetry, indicating large domain movements and reversible pairwise association. RESULTS: The three-dimensional structure of the N-terminal domain of E. coli DnaB was determined by nuclear magnetic resonance (NMR) spectroscopy. Structural similarity was found with the primary dimerisation domain of a topoisomerase, the gyrase A subunit from E. coli. A monomer-dimer equilibrium was observed for the isolated N-terminal domain of DnaB. A dimer model with C2 symmetry was derived from intermolecular nuclear Overhauser effects, which is consistent with all available NMR data. CONCLUSIONS: The monomer-dimer equilibrium observed for the N-terminal domain of DnaB is likely to be of functional significance for helicase activity, by participating in the switch between C6 and C3 symmetry of the helicase hexamer.
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{{ABSTRACT_PUBMED_10404597}}
==About this Structure==
==About this Structure==
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1JWE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWE OCA].
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1JWE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWE OCA].
==Reference==
==Reference==
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[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Helicase]]
[[Category: Helicase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:23:35 2008''

Revision as of 23:23, 27 July 2008

Image:1jwe.png

Template:STRUCTURE 1jwe

NMR Structure of the N-Terminal Domain of E. Coli Dnab Helicase

Template:ABSTRACT PUBMED 10404597

About this Structure

1JWE is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

NMR structure of the N-terminal domain of E. coli DnaB helicase: implications for structure rearrangements in the helicase hexamer., Weigelt J, Brown SE, Miles CS, Dixon NE, Otting G, Structure. 1999 Jun 15;7(6):681-90. PMID:10404597

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