1k4b

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{{STRUCTURE_1k4b| PDB=1k4b | SCENE= }}
{{STRUCTURE_1k4b| PDB=1k4b | SCENE= }}
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'''STRUCTURE OF AGUU RNA TETRALOOP, NMR, 20 STRUCTURES'''
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===STRUCTURE OF AGUU RNA TETRALOOP, NMR, 20 STRUCTURES===
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==Overview==
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RNases III are a family of double-stranded RNA (dsRNA) endoribonucleases involved in the processing and decay of a large number of cellular RNAs as well as in RNA interference. The dsRNA substrates of Saccharomyces cerevisiae RNase III (Rnt1p) are capped by tetraloops with the consensus sequence AGNN, which act as the primary docking site for the RNase. We have solved the solution structures of two RNA hairpins capped by AGNN tetraloops, AGAA and AGUU, using NMR spectroscopy. Both tetraloops have the same overall structure, in which the backbone turn occurs on the 3' side of the syn G residue in the loop, with the first A and G in a 5' stack and the last two residues in a 3' stack. A non-bridging phosphate oxygen and the universal G which are essential for Rnt1p binding are strongly exposed. The compared biochemical and structural analysis of various tetraloop sequences defines a novel family of RNA tetraloop fold with the consensus (U/A)GNN and implicates this conserved structure as the primary determinant for specific recognition of Rnt1p substrates.
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(as it appears on PubMed at http://www.pubmed.gov), where 11743000 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11743000}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4B OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4B OCA].
==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:17:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:32:01 2008''

Revision as of 23:32, 27 July 2008

Image:1k4b.png

Template:STRUCTURE 1k4b

STRUCTURE OF AGUU RNA TETRALOOP, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 11743000

About this Structure

Full experimental information is available from OCA.

Reference

A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III., Wu H, Yang PK, Butcher SE, Kang S, Chanfreau G, Feigon J, EMBO J. 2001 Dec 17;20(24):7240-9. PMID:11743000

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