237d

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{{STRUCTURE_237d| PDB=237d | SCENE= }}
{{STRUCTURE_237d| PDB=237d | SCENE= }}
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'''CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION'''
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===CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION===
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==Overview==
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The crystal structure of the decanucleotide d(CGCAATTGCG)2 has been solved by a combination of molecular replacement and heavy-atom procedures and has been refined to an R factor of 20.2% at 2.7 A. It is not a fully base-paired duplex but has a central core of eight Watson-Crick base pairs flanked by unpaired terminal guanosines and cytosines. These participate in hydrogen-bonding arrangements with adjacent decamer duplexes in the crystal lattice. The unpaired guanosines are bound in the G+C regions of duplex minor grooves. The cytosines have relatively high mobility, even though they are constrained to be in one region where they are involved in base-paired triplets with G.C base pairs. The 5'-AATT sequence in the duplex region has a narrow minor groove, providing further confirmation of the sequence-dependent nature of groove width.
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The line below this paragraph, {{ABSTRACT_PUBMED_7479880}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7479880 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7479880}}
==About this Structure==
==About this Structure==
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[[Category: Flipped-out base]]
[[Category: Flipped-out base]]
[[Category: Intermolecular base triplet]]
[[Category: Intermolecular base triplet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:21:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:32:47 2008''

Revision as of 23:32, 27 July 2008

Image:237d.png

Template:STRUCTURE 237d

CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION

Template:ABSTRACT PUBMED 7479880

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction., Spink N, Nunn CM, Vojtechovsky J, Berman HM, Neidle S, Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10767-71. PMID:7479880

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