2fz4

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{{Seed}}
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{{STRUCTURE_2fz4| PDB=2fz4 | SCENE= }}
{{STRUCTURE_2fz4| PDB=2fz4 | SCENE= }}
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'''Crystal Structure of the N-terminal half of Archaeoglobus Fulgidus XPB'''
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===Crystal Structure of the N-terminal half of Archaeoglobus Fulgidus XPB===
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==Overview==
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The human xeroderma pigmentosum group B (XPB) helicase is essential for transcription, nucleotide excision repair, and TFIIH functional assembly. Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition domain (DRD), a unique RED motif, a flexible thumb motif (ThM), and implied conformational changes within a conserved functional core. RED motif mutations dramatically reduce helicase activity, and the DRD and ThM, which flank the RED motif, appear structurally as well as functionally analogous to the MutS mismatch recognition and DNA polymerase thumb domains. Substrate specificity is altered by DNA damage, such that AfXPB unwinds dsDNA with 3' extensions, but not blunt-ended dsDNA, unless it contains a lesion, as shown for CPD or (6-4) photoproducts. Together, these results provide an unexpected mechanism of DNA unwinding with implications for XPB damage verification in nucleotide excision repair.
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(as it appears on PubMed at http://www.pubmed.gov), where 16600867 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16600867}}
==About this Structure==
==About this Structure==
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[[Category: Dna damage recognition domain]]
[[Category: Dna damage recognition domain]]
[[Category: Reca-like domain]]
[[Category: Reca-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:28:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:36:47 2008''

Revision as of 23:36, 27 July 2008

Image:2fz4.png

Template:STRUCTURE 2fz4

Crystal Structure of the N-terminal half of Archaeoglobus Fulgidus XPB

Template:ABSTRACT PUBMED 16600867

About this Structure

2FZ4 is a Single protein structure of sequence from Archaeoglobus fulgidus dsm 4304. Full crystallographic information is available from OCA.

Reference

Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair., Fan L, Arvai AS, Cooper PK, Iwai S, Hanaoka F, Tainer JA, Mol Cell. 2006 Apr 7;22(1):27-37. PMID:16600867

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