1pg4

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{{STRUCTURE_1pg4| PDB=1pg4 | SCENE= }}
{{STRUCTURE_1pg4| PDB=1pg4 | SCENE= }}
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'''Acetyl CoA Synthetase, Salmonella enterica'''
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===Acetyl CoA Synthetase, Salmonella enterica===
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==Overview==
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Acetyl-coenzyme A synthetase catalyzes the two-step synthesis of acetyl-CoA from acetate, ATP, and CoA and belongs to a family of adenylate-forming enzymes that generate an acyl-AMP intermediate. This family includes other acyl- and aryl-CoA synthetases, firefly luciferase, and the adenylation domains of the modular nonribosomal peptide synthetases. We have determined the X-ray crystal structure of acetyl-CoA synthetase complexed with adenosine-5'-propylphosphate and CoA. The structure identifies the CoA binding pocket as well as a new conformation for members of this enzyme family in which the approximately 110-residue C-terminal domain exhibits a large rotation compared to structures of peptide synthetase adenylation domains. This domain movement presents a new set of residues to the active site and removes a conserved lysine residue that was previously shown to be important for catalysis of the adenylation half-reaction. Comparison of our structure with kinetic and structural data of closely related enzymes suggests that the members of the adenylate-forming family of enzymes may adopt two different orientations to catalyze the two half-reactions. Additionally, we provide a structural explanation for the recently shown control of enzyme activity by acetylation of an active site lysine.
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(as it appears on PubMed at http://www.pubmed.gov), where 12627952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12627952}}
==About this Structure==
==About this Structure==
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[[Category: Amp-forming]]
[[Category: Amp-forming]]
[[Category: Thioester-forming]]
[[Category: Thioester-forming]]
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Revision as of 23:37, 27 July 2008

Image:1pg4.png

Template:STRUCTURE 1pg4

Acetyl CoA Synthetase, Salmonella enterica

Template:ABSTRACT PUBMED 12627952

About this Structure

1PG4 is a Single protein structure of sequence from Salmonella enterica. This structure supersedes the now removed PDB entry 1nnm. Full crystallographic information is available from OCA.

Reference

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A., Gulick AM, Starai VJ, Horswill AR, Homick KM, Escalante-Semerena JC, Biochemistry. 2003 Mar 18;42(10):2866-73. PMID:12627952

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