1tuv

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{{STRUCTURE_1tuv| PDB=1tuv | SCENE= }}
{{STRUCTURE_1tuv| PDB=1tuv | SCENE= }}
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'''Crystal structure of YgiN in complex with menadione'''
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===Crystal structure of YgiN in complex with menadione===
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==Overview==
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Naturally synthesized quinones perform a variety of important cellular functions. Escherichia coli produce both ubiquinone and menaquinone, which are involved in electron transport. However, semiquinone intermediates produced during the one-electron reduction of these compounds, as well as through auto-oxidation of the hydroxyquinone product, generate reactive oxygen species that stress the cell. Here, we present the crystal structure of YgiN, a protein of hitherto unknown function. The three-dimensional fold of YgiN is similar to that of ActVA-Orf6 monooxygenase, which acts on hydroxyquinone substrates. YgiN shares a promoter with "modulator of drug activity B," a protein with activity similar to that of mammalian DT-diaphorase capable of reducing mendione. YgiN was able to reoxidize menadiol, the product of the "modulator of drug activity B" (MdaB) enzymatic reaction. We therefore refer to YgiN as quinol monooxygenase. Modulator of drug activity B is reported to be involved in the protection of cells from reactive oxygen species formed during single electron oxidation and reduction reactions. The enzymatic activities, together with the structural characterization of YgiN, lend evidence to the possible existence of a novel quinone redox cycle in E. coli.
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(as it appears on PubMed at http://www.pubmed.gov), where 15613473 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15613473}}
==About this Structure==
==About this Structure==
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[[Category: Menadione oxidase]]
[[Category: Menadione oxidase]]
[[Category: Monooxygenase]]
[[Category: Monooxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:23:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:37:34 2008''

Revision as of 23:37, 27 July 2008

Image:1tuv.png

Template:STRUCTURE 1tuv

Crystal structure of YgiN in complex with menadione

Template:ABSTRACT PUBMED 15613473

About this Structure

1TUV is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and biochemical evidence for an enzymatic quinone redox cycle in Escherichia coli: identification of a novel quinol monooxygenase., Adams MA, Jia Z, J Biol Chem. 2005 Mar 4;280(9):8358-63. Epub 2004 Dec 21. PMID:15613473

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