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2cdh

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[[Image:2cdh.gif|left|200px]]
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{{STRUCTURE_2cdh| PDB=2cdh | SCENE= }}
{{STRUCTURE_2cdh| PDB=2cdh | SCENE= }}
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'''ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION.'''
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===ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION.===
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==Overview==
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All steps of fatty acid synthesis in fungi are catalyzed by the fatty acid synthase, which forms a 2.6-megadalton alpha6beta6 complex. We have determined the molecular architecture of this multienzyme by fitting the structures of homologous enzymes that catalyze the individual steps of the reaction pathway into a 5 angstrom x-ray crystallographic electron density map. The huge assembly contains two separated reaction chambers, each equipped with three sets of active sites separated by distances up to approximately 130 angstroms, across which acyl carrier protein shuttles substrates during the reaction cycle. Regions of the electron density arising from well-defined structural features outside the catalytic domains separate the two reaction chambers and serve as a matrix in which domains carrying the various active sites are embedded. The structure rationalizes the compartmentalization of fatty acid synthesis, and the spatial arrangement of the active sites has specific implications for our understanding of the reaction cycle mechanism and of the architecture of multienzymes in general.
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The line below this paragraph, {{ABSTRACT_PUBMED_16513976}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16513976 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16513976}}
==About this Structure==
==About this Structure==
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[[Category: Fungal fatty acid synthase]]
[[Category: Fungal fatty acid synthase]]
[[Category: Multifunctional enzyme]]
[[Category: Multifunctional enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:53:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:40:00 2008''

Revision as of 23:40, 27 July 2008

Image:2cdh.png

Template:STRUCTURE 2cdh

ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION.

Template:ABSTRACT PUBMED 16513976

About this Structure

2CDH is a Single protein structure of sequence from Thermomyces lanuginosus. Full crystallographic information is available from OCA.

Reference

Architecture of a fungal fatty acid synthase at 5 A resolution., Jenni S, Leibundgut M, Maier T, Ban N, Science. 2006 Mar 3;311(5765):1263-7. PMID:16513976

Page seeded by OCA on Mon Jul 28 02:40:00 2008

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