1vm1

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{{STRUCTURE_1vm1| PDB=1vm1 | SCENE= }}
{{STRUCTURE_1vm1| PDB=1vm1 | SCENE= }}
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'''STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM'''
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===STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM===
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==Overview==
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Two species resulting from the reaction of the SHV-1 class A beta-lactamase with the sulfone inhibitor tazobactam have been trapped at 100 K and mapped by X-ray crystallography at 2.0 A resolution. An acyclic form of tazobactam is covalently bonded to the catalytic Ser70 side chain, and a second species, a five-atom vinyl carboxylic acid fragment of tazobactam, is bonded to Ser130. It is proposed that the electron density map of the crystal is a composite picture of two complexes, each with only a single bound species. It is estimated that the two complexes exist in the crystal in approximately equal populations. Results are discussed in relation to the mechanism-based inhibition of class A beta-lactamases by the similar inhibitors sulbactam and clavulanic acid.
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(as it appears on PubMed at http://www.pubmed.gov), where 11327849 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11327849}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor design]]
[[Category: Inhibitor design]]
[[Category: Penicillinase]]
[[Category: Penicillinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:42:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:40:08 2008''

Revision as of 23:40, 27 July 2008

Image:1vm1.png

Template:STRUCTURE 1vm1

STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM

Template:ABSTRACT PUBMED 11327849

About this Structure

1VM1 is a Single protein structure of sequence from Klebsiella pneumoniae. This structure supersedes the now removed PDB entry 1g56. Full crystallographic information is available from OCA.

Reference

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam., Kuzin AP, Nukaga M, Nukaga Y, Hujer A, Bonomo RA, Knox JR, Biochemistry. 2001 Feb 13;40(6):1861-6. PMID:11327849

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