1rsb

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{{STRUCTURE_1rsb| PDB=1rsb | SCENE= }}
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'''X-ray study of the DNA oligomer d(ATATAT) in P65 space group'''
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===X-ray study of the DNA oligomer d(ATATAT) in P65 space group===
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==Overview==
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We present and analyze the structure of the oligonucleotide d(ATATAT) found in two different forms by X-ray crystallography and in solution by NMR. We find that in both crystal lattices the oligonucleotide forms an antiparallel double helical duplex in which base pairing is of the Hoogsteen type. The double helix is apparently very similar to the standard B-form of DNA, with about 10 base pairs per turn. However, the adenines in the duplex are flipped over; as a result, the physicochemical features of both grooves of the helix are changed. In particular, the minor groove is narrow and hydrophobic. On the other hand, d(ATATAT) displays a propensity to adopt the B conformation in solution. These results confirm the polymorphism of AT-rich sequences in DNA. Furthermore, we show that extrahelical adenines and thymines can be minor groove binders in Hoogsteen DNA.
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==About this Structure==
==About this Structure==
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[[Category: Subirana, J A.]]
[[Category: Subirana, J A.]]
[[Category: Antiparallel hoogsteen dna]]
[[Category: Antiparallel hoogsteen dna]]
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Revision as of 23:41, 27 July 2008

Image:1rsb.png

Template:STRUCTURE 1rsb

X-ray study of the DNA oligomer d(ATATAT) in P65 space group

Template:ABSTRACT PUBMED 15065851

About this Structure

Full crystallographic information is available from OCA.

Reference

X-ray and NMR studies of the DNA oligomer d(ATATAT): Hoogsteen base pairing in duplex DNA., Abrescia NG, Gonzalez C, Gouyette C, Subirana JA, Biochemistry. 2004 Apr 13;43(14):4092-100. PMID:15065851

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