1t7k

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[[Image:1t7k.gif|left|200px]]
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{{STRUCTURE_1t7k| PDB=1t7k | SCENE= }}
{{STRUCTURE_1t7k| PDB=1t7k | SCENE= }}
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'''Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea'''
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===Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea===
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==Overview==
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A series of novel azacyclic urea HIV protease inhibitors bearing a benzenesulfonamide group at P1' were synthesized utilizing a parallel synthesis method. Structural studies of early analogs bound in the enzyme active site were used to design more potent inhibitors. The effects of substituting the P1' benzenesulfonyl group on antiviral activity and protein binding are described.
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(as it appears on PubMed at http://www.pubmed.gov), where 15225729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15225729}}
==About this Structure==
==About this Structure==
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[[Category: Arylsulfonamide azacyclic urea]]
[[Category: Arylsulfonamide azacyclic urea]]
[[Category: Hiv protease]]
[[Category: Hiv protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:38:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:41:50 2008''

Revision as of 23:41, 27 July 2008

Template:STRUCTURE 1t7k

Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea

Template:ABSTRACT PUBMED 15225729

About this Structure

1T7K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors., Huang PP, Randolph JT, Klein LL, Vasavanonda S, Dekhtyar T, Stoll VS, Kempf DJ, Bioorg Med Chem Lett. 2004 Aug 2;14(15):4075-8. PMID:15225729

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