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1tv0

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[[Image:1tv0.gif|left|200px]]
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{{STRUCTURE_1tv0| PDB=1tv0 | SCENE= }}
{{STRUCTURE_1tv0| PDB=1tv0 | SCENE= }}
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'''Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells'''
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===Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells===
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==Overview==
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Mammalian defensins are abundant antimicrobial peptides that contribute to host defense. They are characterized by several conserved amino acids, including six invariant cysteine residues which form three intramolecular disulfide bonds and stabilize the tertiary structure. Cryptdin-4 (Crp4), a mouse alpha-defensin with potent in vitro bactericidal activity, has a primary structure distinct from all known alpha-defensins in that its polypeptide backbone uniquely lacks three residues between Cys(IV) and Cys(V). NMR diffusion experiments showed that Crp4 is monomeric in solution, and its three-dimensional solution structure, determined by two-dimensional proton NMR, consists of a triple-stranded antiparallel beta-sheet with the beta-strands joined to each other by a series of tight turns and a beta-hairpin. However, the overall beta-sheet content in Crp4 is lower than that of other alpha-defensin structures, while the shape and orientation of the Crp4 beta-hairpin also differ from those of other alpha-defensin structures. These structural characteristics combined with the high overall cationicity of Crp4 may contribute to its broad bactericidal spectrum and membrane disruptive activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_15595831}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15595831 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15595831}}
==About this Structure==
==About this Structure==
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1TV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].
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1TV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].
==Reference==
==Reference==
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[[Category: Beta hairpin]]
[[Category: Beta hairpin]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:24:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:45:03 2008''

Revision as of 23:45, 27 July 2008

Image:1tv0.png

Template:STRUCTURE 1tv0

Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells

Template:ABSTRACT PUBMED 15595831

About this Structure

1TV0 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin., Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ, Biochemistry. 2004 Dec 21;43(50):15759-66. PMID:15595831

Page seeded by OCA on Mon Jul 28 02:45:03 2008

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