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2c5j

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[[Image:2c5j.gif|left|200px]]
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{{STRUCTURE_2c5j| PDB=2c5j | SCENE= }}
{{STRUCTURE_2c5j| PDB=2c5j | SCENE= }}
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'''N-TERMINAL DOMAIN OF TLG1, DOMAIN-SWAPPED DIMER'''
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===N-TERMINAL DOMAIN OF TLG1, DOMAIN-SWAPPED DIMER===
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==Overview==
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Membrane fusion in cells involves the interaction of SNARE proteins on apposing membranes. Formation of SNARE complexes is preceded by tethering events, and a number of protein complexes that are thought to mediate this have been identified. The VFT or GARP complex is required for endosome-Golgi traffic in yeast. It consists of four subunits, one of which, Vps51, has been shown to bind specifically to the SNARE Tlg1, which participates in the same fusion event. We have determined the structure of the N-terminal domain of Tlg1 bound to a peptide from the N terminus of Vps51. Binding depends mainly on residues 18-30 of Vps51. These form a short helix which lies in a conserved groove in the three-helix bundle formed by Tlg1. Surprisingly, although both Vps51 and Tlg1 are required for transport to the late Golgi from endosomes, removal of the Tlg1-binding sequences from Vps51 does not block such traffic in vivo. Thus, this particular interaction cannot be crucial to the process of vesicle docking or fusion.
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(as it appears on PubMed at http://www.pubmed.gov), where 16420526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16420526}}
==About this Structure==
==About this Structure==
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[[Category: Snare]]
[[Category: Snare]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:17:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:45:15 2008''

Revision as of 23:45, 27 July 2008

Image:2c5j.png

Template:STRUCTURE 2c5j

N-TERMINAL DOMAIN OF TLG1, DOMAIN-SWAPPED DIMER

Template:ABSTRACT PUBMED 16420526

About this Structure

2C5J is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural analysis of the interaction between the SNARE Tlg1 and Vps51., Fridmann-Sirkis Y, Kent HM, Lewis MJ, Evans PR, Pelham HR, Traffic. 2006 Feb;7(2):182-90. PMID:16420526

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